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Inflammation of the heart after reperfused myocardial infarction
In this issue, Edward Thorp explains that AXL uniquely promotes a switch to glycolytic metabolism and inflammatory cytokine production by macrophages to worsen ventricular remodeling and lead to heart failure after myocardial infarction...
Published March 15, 2021
Author's Take
N-cadherin upregulation in glioblastoma
In this episode, Erwin Van Meir and Satoru Osuka eplain that glioma stem cells adapt to the toxicity of repeated irradiation by upregulating N-cadherin, and this resistance pathway can be antagonized by blocking the IGF1 receptor...
Published March 15, 2021
Author's Take
Protecting kidney from fibrosis by enhancing fatty acid oxidation
In this episode, Santiago Lamas and VerĂ³nica Miguel explain that strategies based on FAO-GOF may constitute powerful alternatives to combat fibrosis inherent to CKD...
Published March 1, 2021
Author's Take
Targeting a Braf/Mapk pathway in CoQ-deficiency kidney disease
In this episode, Ana Greka and Eriene-Heidi Sidhom explain that an investigation of cell-specific disease mechanisms in rare genetic disorder revealed Braf/Mapk as a candidate pathway for the treatment of kidney diseases...
Published March 1, 2021
Author's Take
The COVID-19 immune landscape correlation with disease severity
In this episode, Jane Buckner explains a longitudinal analysis of acute COVID-19 ranging from mild to severe disease determining immune trajectories of recovery...
Published February 1, 2021
Author's Take
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