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The JCI's 2010 Impact Factor is 14.152
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February 2012: View the entire issue
Cover story: Taming tumor hypoxia and metabolism
Human tumor cells stained for DAPI (blue), cytochrome c (red), and CHCHD4 (green). The HIF pathway plays a central role in sensing and responding to changes in cellular oxygen levels, and, since increased expression of HIF-α is observed in many human cancers, understanding how HIF-α becomes deregulated in cancer could lead to new therapeutic strategies. In their manuscript, Yang and colleagues (page 600) provide a novel mitochondrial link to hypoxia signaling. They identify and characterize a role for the CHCHD4 mitochondrial proteins in regulating HIF-α signaling, angiogenesis, and tumor progression.
Also inside:
Though it's the first thing we see when we look at each other, the skin may be occasionally forgotten as a site of clinically important disease. The reviews in this series highlight our current understanding of several common dermatological conditions, and describe how research in the field has played a major role in expanding our understanding of the basic biology of stem cells and cancer. Correspondingly, basic research findings have led to new insights into dermatological disease, often with impact on therapeutic strategies. Cover image credit: John Seykora
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Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer
Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice
Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice
Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets
FOSL2 promotes leptin gene expression in human and mouse adipocytes
The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia
A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration