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Eva van Rooij, Eric N. Olson
J Clin Invest. 2007;
117(9):2369
doi:10.1172/JCI33099
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icroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.
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