Submit a Letter to the Editor for:
Jane E. Salmon
J Clin Invest. 2004;
114(1):15
doi:10.1172/JCI22258
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lthough the mechanisms of immune-mediated pregnancy loss are unknown, investigations are currently focused on mediators of immune activation and tissue injury at the maternal-fetal interface. A new study, however, demonstrates that systemic inflammatory mediators can induce pregnancy failure in a different way, by inhibiting ovarian hormone production, and identifies links between the immune and reproductive endocrine systems.
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