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Marcus Svensson, Jan Marsal, Anna Ericsson, Laura Carramolino, Therese Brodén, Gabriel Márquez, William W. Agace
J Clin Invest. 2002;
110(8):1113
doi:10.1172/JCI15988
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he recruitment of antigen-specific T lymphocytes to the intestinal mucosa is central to the development of an effective mucosal immune response, yet the mechanism by which this process occurs remains to be fully defined. Here we show that the CC chemokine receptor 9 (CCR9) is selectively and functionally expressed on murine αEβ7+ naive CD8αβ+ lymphocytes and a subset of recently activated CD69+ CD8αβ+ lymphocytes. Using a T cell receptor transgenic transfer model, we demonstrate that CCR9 expression is functionally maintained on CD8αβ+ lymphocytes following activation in mesenteric lymph nodes but rapidly downregulated on CD8αβ+ lymphocytes activated in peripheral lymph nodes. These recently activated CCR9+ CD8αβ+ lymphocytes selectively localized to the small-intestinal mucosa, and in vivo neutralization of the CCR9 ligand, CCL25, reduced the ability of these cells to populate the small-intestinal epithelium. Together these results demonstrate an important role for chemokines in the localization of T lymphocytes to the small-intestinal mucosa and suggest that targeting CCL25 and/or CCR9 may provide a means to selectively modulate small-intestinal immune responses.
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