Regular ArticleTraumatic Brain Injury Leads to Increased Expression of Peripheral-Type Benzodiazepine Receptors, Neuronal Death, and Activation of Astrocytes and Microglia in Rat Thalamus
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2019, Pharmacology and TherapeuticsCitation Excerpt :The number of ED-1 or GFAP positive cells were both shown to significantly correlate with [3H]PK11195 binding but it was noted that there was a “better” correlation with ED-1 than with GFAP. The authors seem to disregard the astrocytic TSPO response with the statement that “microglia/macrophages are the major cell type associated with the increased TSPO expression following TBI” while considering that “the possibility of some astroglial contribution to the increased TSPO expression following TBI cannot be ruled out” (Rao et al., 2000). Regardless of their interpretation of the results, one experimental limitation of this study is that cell counting did not use unbiased stereological cell counting methods nor was a description of the morphological or cell size criteria used to count cell number was provided.
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