Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1
J. Clin. Invest. Hanna Huopio, et al. 106:897 doi:10.1172/JCI9804 [Go to this article.]

Figure 6
Effects of MgADP, tolbutamide, and diazoxide on Kir6.2/SUR1-E1506K currents. (a) Macroscopic Kir6.2/SUR1-E1506K currents recorded from inside-out patches in response to series of voltage ramps from –110 mV to +100 mV. Tolbutamide (100 μM), ADP (100 μM), diazoxide (340 μM), and ATP (100 μM) were added to the internal solution as indicated by the bars. (b) Mean macroscopic slope conductance recorded in the presence of ATP, ATP plus diazoxide, ADP, or tolbutamide, expressed as percentage of the slope conductance in control solution. The number of oocytes is given above the bars. Inset: Mean macroscopic slope conductance recorded in the presence of 100 μM ATP plus 340 μM diazoxide, expressed as a percentage of the current in the presence of 100 μM ATP for Kir6.2/SUR and Kir6.2/SUR1-E1506K currents. The dashed line indicates the conductance in the presence of 100 μM ATP. The number of oocytes is given above the bars.