Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1
J. Clin. Invest. Hanna Huopio, et al. 106:897 doi:10.1172/JCI9804 [Go to this article.]

Figure 5
(a) Current amplitudes recorded in excised patches. Mean current amplitudes recorded at –100 mV in the cell-attached or inside-out patch configuration from oocytes co-injected with Kir6.2 and either SUR1 or SUR-E1506K as indicated. The number of oocytes is given above the bars. (b) ATP sensitivity of Kir6.2/SUR1-E1506K currents; mean ATP concentration-response relationships for Kir6.2/SUR1-E1506K currents (n = 4). The slope conductance (G) is expressed as a fraction of the mean (G_c) of that obtained in control solution before and after the exposure to ATP: The line is the best fit of the data to Hill equation (IC₅₀ = 9.3 μM and h = 0.96).