Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1
J. Clin. Invest. Hanna Huopio, et al. 106:897 doi:10.1172/JCI9804 [
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Figure 4Effects of metabolic inhibition on wild-type and mutant Kir6.2/SUR1 currents. Mean whole-cell current amplitudes recorded at –50 mV first in control solution (black bars), 15 minutes after exposure to 3 mM azide (hatched bars), then in the continued presence of azide plus 340 μM diazoxide (white bars), and, finally, after the further addition of 500 μM tolbutamide (shaded bars). Oocytes were co-injected with mRNA encoding Kir6.2 and either SUR1, SUR1-E1506K, or a 1:1 mixture of SUR1 plus SUR1-E1506K, as indicated. The number of oocytes is given above the error bars.
