Host cyclooxygenase-2 modulates carcinoma growth
J. Clin. Invest. Christopher S. Williams, et al. 105:1589 doi:10.1172/JCI9621 [Go to this article.]

Figure 6
VEGF production in fibroblasts is regulated by COX-2. Production of VEGF by wild-type, COX-1^–/–, and COX-2^–/– fibroblasts was determined. Each treatment condition is listed below its respective bar graph. WT denotes wild-type mouse fibroblasts. We observed a 93% reduction in VEGF production in COX-2^–/– fibroblasts when compared with wild-type fibroblasts. Additionally, treatment of wild-type fibroblasts with a selective COX-2 inhibitor (10 μM SC-58125) led to a ∼90% reduction in VEGF levels.