In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium
J. Clin. Invest. Thomas J. Kelley, et al. 106:403 doi:10.1172/JCI9560 [
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Figure 4IRF-1 expression in CF and non-CF epithelial tissue. (
a) Representative blot of IRF-1 protein expression in excised nasal epithelium from
CFTR+/– mice (lanes 1–3) and
CFTR–/– mice (lanes 4–6). Each lane represents tissue isolated from individual mice. (
c) IRF-1 expression in excised epithelial tissue from sections of ileum isolated from a
CFTR+/– mouse (lane 1), an FABP-h
cftr mouse (lane 2), and a
CFTR–/– mouse (lane 3). (
b and
d) Densitometric analysis of IRF-1–specific immunoblots. Number of samples (
n) is shown in parentheses above each bar. Significance determined by Student’s
t test. Error bars represent SEM. NS, no significant difference between these two values. IB, immunoblot.
