In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium
J. Clin. Invest. Thomas J. Kelley, et al. 106:403 doi:10.1172/JCI9560 [
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Figure 3Murine nasal transepithelial chloride transport is partially IRF-1 dependent. Changes in TEPD in response to perfusion with chloride-free Ringer’s solution were measured in wild-type C57BL/6J mice (filled squares;
n = 6),
IRF-1–/– mice (open circles;
n = 8), and
IRF-1–/– mice with SNP (100 μM) added to the perfusion solution (filled triangles;
n = 5). Error bars represent SEM. Time zero refers to the point at which the perfusion solution was changed to chloride-free Ringer’s (this was done when a plateau value was reached in chloride-replete Ringer’s containing amiloride). Amiloride (100 μM) was present in all perfusion solutions.
