Junctional communication of pancreatic β cells contributes to the control of insulin secretion and glucose tolerance
J. Clin. Invest. Anne Charollais, et al. 106:235 doi:10.1172/JCI9398 [Go to this article.]

Figure 5
Transgenic mice expressing Cx32 show altered tolerance to glucose. (a) After challenge with 0.11 mg/g body weight glucose, the blood levels of the sugar increased in all mice to 145–180 mg/dL. In controls (solid squares), glycemia returned to basal values within 1 hour. In contrast, the glycemia of most heterozygous (open triangles) and homozygous (inverted triangles) transgenic mice did not return to the initial basal levels, which were lower (P < 0.003) than those of controls, during the 2 hours of the test. Data are mean ± SEM of the indicated number of animals tested at all time points / only at time 0. (b) The ratio of glucose-stimulated/basal glycemia averaged one in control mice (open bars) from time 60 minutes after the glucose challenge onward, but was significantly higher in both heterozygous (gray bars) and homozygous (solid bars) mice. Data are mean ± SEM of the indicated number of animals. ^AP < 0.02, ^BP < 0.001 compared with controls.