Junctional communication of pancreatic β cells contributes to the control of insulin secretion and glucose tolerance
J. Clin. Invest. Anne Charollais, et al. 106:235 doi:10.1172/JCI9398 [Go to this article.]

Figure 3
Cx32 increases coupling of pancreatic β cells. (a and b) Microinjection resulted in an intercellular transfer of Lucifer Yellow that was limited within islets isolated from control mice (a) and much larger within islets isolated from transgenic animals (b). (c and d) Sections of the injected areas showed that the number of β cells that exchanged Lucifer Yellow was larger in transgenic (d) than control (c) islets. Scale bar: 120 μm (a and b), 17 μm (c and d). (e and f) Dye coupling was 30- to 40-fold larger in transgenic (solid column and circles) than control mice (open column and squares). Data in e are mean ± SEM of the indicated number of islets. Symbols in f represent individual islets; bar = median. LY, Lucifer Yellow.