A chemokine-to-cytokine-to-chemokine cascade critical in antiviral defense
J. Clin. Invest. Thais P. Salazar-Mather, et al. 105:985 doi:10.1172/JCI9232 [Go to this article.]

Figure 3
Effects of MIP-1α and IFN-γ on resistance to MCMV. (a and b) MIP-1α⁺, MIP-1α^–, IFN-γ^–/– (IFN-γ^–), and MIP-1α^– IFN-γ^– mice were uninfected or infected with 5 × 10⁴ PFU MCMV at times indicated. Spleen (a) and livers (b) were harvested and homogenized for viral titer determinations as described in Methods. Limit of detection for the assay was 2 log PFU per gram of tissue. Means ± SE (n = 3) are shown. (c) Mice were uninfected or infected with 10⁵ PFU (high dose) MCMV and monitored twice daily for survival. Results represent 1 of at least 2 experiments. Data shown represent the mean ± SE (n = 6).