T cell–mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis
J. Clin. Invest. Axel Trautmann, et al. 106:25 doi:10.1172/JCI9199 [Go to this article.]

Figure 5
Features of inflammation in AD. Immunohistologic staining with 3-amino-9-ethylcarbazole substrate and counterstaining with hematoxylin. (a) Subepidermal inflammatory infiltrate, consisting mainly of lymphocytes. ×100. (b) CD4⁺ cells infiltrating the spongiotic epidermis. ×200. (c) CD8⁺ cells. ×200. (d) FasL⁺ cells in the dermal cellular infiltrate. ×200. (e) Strong immunoreactivity of FasR in the basal epidermis; weaker staining in the T-cell infiltrate. ×100. (f) Detection of IFN-γ receptor on KCs and infiltrating T cells. ×200.