C-C chemokine–encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis
J. Clin. Invest. Sawsan Youssef, et al. 106:361 doi:10.1172/JCI9109 [Go to this article.]

Figure 4
Self-specific Ab’s to the gene product of each DNA vaccine are continually produced during the acute and the chronic phase of disease. Lewis rats were subjected to the administration of various C-C chemokine DNA constructs, as described in Figure 1. Control rats were injected with pcDNA3 alone or with PBS. Three weeks later these rats were administered CFA to induce poly-arthritis. At different time points the kinetics of anti-self Ab appearance in serum was determined by ELISA. Results are shown as mean of three different serum samples ± SE.