C-C chemokine–encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis
J. Clin. Invest. Sawsan Youssef, et al. 106:361 doi:10.1172/JCI9109 [
Go to this article.]
Figure 2DNA vaccination with C-C chemokines reduces the severity of histological changes in the acute phase of AA in rats. Representative sections from Table
1 are presented. (
a–
g) Representative synovial joints (×5). (
h–
n) Representative synovial tissue (×40). Parts
a and
h show naive rat joint;
b and
i show an arthritic joint;
c and
j show joint from rat vaccinated with pcDNA3 vector alone;
d and
k show representative joint from rats vaccinated with MCP-1;
e and
l show representative joint from rats vaccinated with MIP-1α;
f and
m show representative joints from rats vaccinated with MIP-1β;
g and
n show representative joints from rats vaccinated with RANTES. The arrowheads point to the synovial lining. Histological evaluation was done by an observer blind to the experimental protocol. b, bone; nb, new bone formation; s, synovial membrane.
