Deactivation of peroxisome proliferator–activated receptor-α during cardiac hypertrophic growth
J. Clin. Invest. Philip M. Barger, et al. 105:1723 doi:10.1172/JCI9056 [Go to this article.]

Figure 1
Palmitate oxidation rates decrease during cardiac myocyte hypertrophy. Shown is total ¹⁴CO₂ (in counts per minute, CPM) elaborated over a 24-hour period by the oxidation of [1-¹⁴C]palmitate in cardiac myocytes after exposure to either the α₁-adrenergic agonist PE (100 μM) or vehicle (water) control (C) for 72 hours. CPM was determined by scintillation counting (as described in Methods and corrected for cell number), and was normalized to the value obtained in vehicle-treated control cells (= 100%). ^ASignificantly different (P < 0.001 by Student’s t test) from control. These results represent the mean ± SEM of duplicate conditions in three independent experiments.