Developing erythrocytes take up exceptionally large amounts of iron, which must be transferred to mitochondria for incorporation into heme. This massive iron flux must be precisely controlled to permit the coordinated synthesis of heme and hemoglobin while avoiding the toxic effects of chemically reactive iron. In cultured animal cells, iron chaperones
Moon-Suhn Ryu, Deliang Zhang, Olga Protchenko, Minoo Shakoury-Elizeh, Caroline C. Philpott
PCBP1 and NCOA4 activities are differentially regulated during rbc maturation in G1E-ER4 cells.
Cells were treated with β-estradiol (β-Est), EPO, and 55Fe2-Tf for 48 hours. (