Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene
J. Clin. Invest. S. Eddahibi, et al. 105:1555 doi:10.1172/JCI8678 [Go to this article.]

Figure 7
Immunohistochemical localization of 5-HTT in distal pulmonary vessels from a 5-HTT^+/+ mouse (a) and a 5-HTT^–/– mutant mouse (b) exposed to hypoxia for 2 weeks. In the pulmonary vessels from wild-type mice, dense immunostaining is visible in the smooth muscle cells. In contrast, only a very low level of background staining is observed in vessels from 5-HTT^–/– mice. Scale bar, 25 μm.