Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene
J. Clin. Invest. S. Eddahibi, et al. 105:1555 doi:10.1172/JCI8678 [
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Figure 4Distribution of vessels according to the accompanying airway. Fifty to 60 intraacinar vessels were analysed in each lung from mice of each genotype after exposure to hypoxia for 2 weeks (
n = 9 of each genotype) or 5 weeks (
n = 8 of each genotype). Percentages of nonmuscular (NM), partially muscular (PM), or fully muscular (M) vessels determined separately at the alveolar duct and alveolar wall levels differed significantly between
5-HTT+/+ and
5-HTT–/– mice after exposure to hypoxia for either 2 weeks (
P < 0.01) or 5 weeks (
P < 0.001).
