Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene
J. Clin. Invest. S. Eddahibi, et al. 105:1555 doi:10.1172/JCI8678 [Go to this article.]

Figure 2
Individual and mean (horizontal line) values of RVSP in normoxic 5-HTT^+/+ and 5-HTT^–/– mice under ventilation with room air (normoxia) and after 5 minutes of ventilation with a hypoxic gas mixture (hypoxia). Baseline RVSP under normoxic ventilation did not differ between 5-HTT^+/+ and 5-HTT^–/– mice. The RVSP increase during acute hypoxia was significantly larger in 5-HTT^–/– than in 5-HTT^+/+ mice (P < 0.01).