Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1
J. Clin. Invest. Mark A. Sussman, et al. 105:875 doi:10.1172/JCI8497 [Go to this article.]

Figure 5
Myofibril organization in racET hearts is not disrupted. Confocal (a–c) and electron microscopy (d–e) showing myofibril organization in control ntg (a, d) or racET (b, c, e) heart sections. Organized Z-discs labeled with α-actinin antibody showed typical striated patterns in control (a), dilated racET (b), and hypertrophic racET (c) sections. Electron microscopy shows normal cardiomyocyte interior (d) in comparison with racET cardiomyocyte (e) containing granular material (g) occasionally observed near the cell center. Electron microscopy samples were prepared and viewed as described previously (51). Bar: (a–c) 30 μm; (d) 7.7 μm; and (e) 3.2 μm.