Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1
J. Clin. Invest. Mark A. Sussman, et al. 105:875 doi:10.1172/JCI8497 [Go to this article.]

Figure 4
Comparison of mRNA expression levels in hearts of racET mice. Analyses of cardiac gene expression for genes that may be involved in hypertrophic/failure responses. Results are shown as fold increase for racET mice mRNA relative to ntg levels. Equivalent expression between controls and racET mice is presented as 1 (baseline) with values above and below 1 representing increased and decreased expression, respectively. Values were determined from average expression of five individual racET samples. Standard deviations (SD) are percent variation of fold increase. Significance was calculated relative to MLC-2V. Error bars represent standard error of the mean. Signals were normalized for variations in loading with respect to GAPDH. ANF, atrial natriuretic factor; SERCA, sarco/endoplasmic reticulum Ca²⁺-ATPase.