Systemically derived large intestinal CD4⁺ Th2 cells play a central role in STAT6-mediated allergic diarrhea
J. Clin. Invest. Mi-Na Kweon, et al. 106:199 doi:10.1172/JCI8490 [Go to this article.]

Figure 5
Preferential migration of systemically primed splenic GFP⁺ CD4⁺ T cells into large intestines of SCID mice. (a) Migration pattern of GFP⁺ T cells obtained from the spleen and small and large intestines of SCID mice to which GFP⁺ CD4⁺ T cells have been adoptively transferred. (b) Histological analysis of spleen and small and large intestines isolated from recipient SCID mice. Original magnification of ×40 or ×100 was used. (c) Expression of Th1 (IFN-γ) and Th2 (IL-4, IL-5, and IL-13) cytokine–specific mRNA in lymphocytes obtained from the spleen and small and large intestine of recipient SCID mice. (d) Represents the frequency of IFN-γ– and IL-4–secreting cells as determined by intracellular cytokine staining. Representative results from two individual experiments are shown.