Systemically derived large intestinal CD4⁺ Th2 cells play a central role in STAT6-mediated allergic diarrhea
J. Clin. Invest. Mi-Na Kweon, et al. 106:199 doi:10.1172/JCI8490 [Go to this article.]

Figure 2
Selective induction of brisk B-cell responses in the large intestine of mice with diarrhea. (a) Total and OVA-specific IgE Ab’s in serum and total IgE AFCs in the small and large intestines. For evaluation of the numbers of IgE positive–staining cells in the large intestine, ten randomly selected fields were counted under ×200. (b) Represents OVA-specific IgG and IgA AFCs in the spleen and in the small and large intestines. The inset shows the frequency of OVA-specific IgG subclass AFCs in the large intestines of mice with diarrhea. Mononuclear cells were isolated from spleen and small and large intestines of control (open bars) and diarrhea-induced mice (filled bars). These data are representative of three independent experiments containing five to seven mice in each group. ^AP < 0.05, ^BP < 0.01 versus control mice. ND, not detectable.