Albuterol-induced downregulation of Gsα accounts for pulmonary β₂-adrenoceptor desensitization in vivo
J. Clin. Invest. Paul A. Finney, et al. 106:125 doi:10.1172/JCI8374 [Go to this article.]

Figure 4
Effect of chronic treatment of rats with albuterol on β₂-adrenoceptor signaling in lung ex vivo. Rats were given saline (filled bars) or albuterol (open bars; 40 μg/kg/h) for 7 days, and albuterol-induced PKA activation (a) and PGE₂-induced cAMP accumulation (b) in lung were determined. Each bar represents the mean ± SEM of eight determinations. ^AP < 0.05, cAMP accumulation and PKA activation significantly attenuated in lung from albuterol-treated rats.