JCI - Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines

Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines

Rohit N. Kulkarni, Jonathon N. Winnay, Molly Daniels, Jens C. Brüning, Sarah N. Flier, Douglas Hanahan, C. Ronald Kahn

Published in Volume 104, Issue 12

J Clin Invest. 1999; 104(12):R69 doi:10.1172/JCI8339

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Title and authors	Publication	Year	.
Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E F. Fiory, A. Lombardi, C. Miele, J. Giudicelli, F. Beguinot, E. Obberghen	Diabetologica	2011	.
Insulin enhances glucose-stimulated insulin secretion in healthy humans C. Bouche, X. Lopez, A. Fleischman, A. M. Cypess, S. O'Shea, D. Stefanovski, R. N. Bergman, E. Rogatsky, D. T. Stein, C. R. Kahn, R. N. Kulkarni, A. B. Goldfine	Proc Natl Acad Sci U S A	2010	.
Slow and steady is the key to β-cell replication Kristen Brennand, Doug Melton	J Cell Mol Med	2009	.
Growth factor control of pancreatic islet regeneration and function Anke Assmann, Charlotte Hinault, Rohit N Kulkarni	Pediatr Diabetes	2009	.
Crucial role of insulin receptor substrate-2 in compensatory β-cell hyperplasia in response to high fat diet-induced insulin resistance I. Takamoto, Y. Terauchi, N. Kubota, M. Ohsugi, K. Ueki, T. Kadowaki	Diabetes Obes Metab	2008	.
Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion. Marta L. Hribal, F. Tornei, A. Pujol, R. Menghini, D. Barcaroli, D. Lauro, R. Amoruso, R. Lauro, F. Bosch, G. Sesti, M. Federici	J Cell Mol Med	2008	.
Insulin Signaling in the Pancreatic β-Cell Ingo B. Leibiger, Barbara Leibiger, Per-Olof Berggren	Annu Rev Nutr	2008	.
IGF-1 Protects Against Dexamethasone-Induced Cell Death in Insulin Secreting INS-1 Cells Independent of AKT/PKB Phosphorylation Diana Avram, Felicia Ranta, Anita M. Hennige, Susanne Berchtold, Sabine Hopp, Hans-Ulrich Häring, Florian Lang, Susanne Ullrich	Cell Physiol Biochem	2008	.
Does IGF-I stimulate pancreatic islet cell growth? Jun-Li Liu	CBB	2007	.
Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice J. Cantley, A. I. Choudhury, H. Asare-Anane, C. Selman, S. Lingard, H. Heffron, P. Herrera, S. J. Persaud, D. J. Withers	Diabetologica	2007	.
From the Cover: Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance T. Okada, C. W. Liew, J. Hu, C. Hinault, M. D. Michael, J. Krtzfeldt, C. Yin, M. Holzenberger, M. Stoffel, R. N. Kulkarni	Proc Natl Acad Sci U S A	2007	.
Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk Christoph Handschin, Cheol Soo Choi, Sherry Chin, Sheene Kim, Dan Kawamori, Amarnath J. Kurpad, Nicole Neubauer, Jiang Hu, Vamsi K. Mootha, Young-Bum Kim, Rohit N. Kulkarni, Gerald I. Shulman, Bruce M. Spiegelman	Journal Clinical Investigation	2007	.
Total insulin and IGF-I resistance in pancreatic β cells causes overt diabetes Kohjiro Ueki, Terumasa Okada, Jiang Hu, Chong Wee Liew, Anke Assmann, Gabriella M Dahlgren, Jennifer L Peters, Jonathan G Shackman, Min Zhang, Isabella Artner, Leslie S Satin, Roland Stein, Martin Holzenberger, Robert T Kennedy, C Ronald Kahn, Rohit N Kulkarni	Natural Genetics	2006	.
Conditional Expression of Smad7 in Pancreatic β Cells Disrupts TGF-β Signaling and Induces Reversible Diabetes Mellitus Nora G. Smart, Åsa A. Apelqvist, Xueying Gu, Erin B. Harmon, James N. Topper, Raymond J. MacDonald, Seung K. Kim	Plos Biol	2006	.
The plecomacrolide vacuolar-ATPase inhibitor bafilomycin, alters insulin signaling in MIN6 β-cells K. D. Hettiarachchi, P. Z. Zimmet, M. A. Myers	Cell Biol Toxicol	2006	.
Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes Z. Asghar, D. Yau, F. Chan, D. LeRoith, C. B. Chan, M. B. Wheeler	Diabetologica	2005	.
New Insights into the Roles of Insulin/IGF-I in the Development and Maintenance of β-Cell Mass Rohit N. Kulkarni	Rev Endocr Metab Disord	2005	.
The role of insulin receptor substrate 2 in hypothalamic and β cell function Agharul I. Choudhury, Helen Heffron, Mark A. Smith, Hind Al-Qassab, Allison W. Xu, Colin Selman, Marcus Simmgen, Melanie Clements, Marc Claret, Gavin MacColl, David C. Bedford, Kazunari Hisadome, Ivan Diakonov, Vazira Moosajee, Jimmy D. Bell, John R. Speakman, Rachel L. Batterham, Gregory S. Barsh, Michael L.J. Ashford, Dominic J. Withers	Journal Clinical Investigation	2005	.
Transgenic rescue of insulin receptor–deficient mice Haruka Okamoto, Jun Nakae, Tadahiro Kitamura, Byung-Chul Park, Ioannis Dragatsis, Domenico Accili	Journal Clinical Investigation	2004	.
Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus Naoto Kubota, Yasuo Terauchi, Kazuyuki Tobe, Wataru Yano, Ryo Suzuki, Kohjiro Ueki, Iseki Takamoto, Hidemi Satoh, Toshiyuki Maki, Tetsuya Kubota, Masao Moroi, Miki Okada-Iwabu, Osamu Ezaki, Ryozo Nagai, Yoichi Ueta, Takashi Kadowaki, Tetsuo Noda	Journal Clinical Investigation	2004	.

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