Increased susceptibility of cerulein-induced pancreatitis was noted in pS2-dnRII mice compared with wild-type littermates. (a) The EI was significantly higher in pS2-dnRII mice, which indicates that more severe edematous pancreatitis developed in pS2-dnRII mice than in wild-type littermates. (b) Serum amylase levels were significantly higher in pS2-dnRII mice (P < 0.001). (c) Changes in pancreatic MPO activities. PS2-dnRII mice showed significantly higher levels of pancreatic MPO activities than wild-type mice (P < 0.01). (d) Histologic activity index was also significantly higher in pS2-dnRII mice. Filled bar indicates pS2-dnRII transgenic mice from pS1 and pS2 lines; open bar indicates wild-type littermates.