Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury
J. Clin. Invest. Fabiola Terzi, et al. 106:225 doi:10.1172/JCI8315 [Go to this article.]

Figure 5
Cell proliferation and collagen accumulation in control (a and d) and postischemic kidneys (b, c, e, f) from wild-type (a, b, d, e) and transgenic (c and f) mice. (a–c) PCNA immunostaining, 2 days after PRI. PRI induced proliferation of tubular cells (compare b with a), which was markedly reduced by transgene expression (compare c with b). (d–f) Sirius red staining, 28 days after ischemia. PRI induced interstitial collagen accumulation (compare e with d), which was markedly reduced by transgene expression (compare f with e). ×200.