Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury
J. Clin. Invest. Fabiola Terzi, et al. 106:225 doi:10.1172/JCI8315 [
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Figure 4Morphology of control (
a and
b) and postischemic kidneys (
c and
d) from wild-type (
a and
c) and transgenic (
b and
d) mice, 28 days after ischemia. Prolonged renal ischemia induced tubular atrophy, interstitial fibrosis, and mononuclear cell infiltrates (compare
c to
a and
b), which were reduced by transgene expression (compare
d to
c). Masson’s trichrome staining, ×200.