Gabriel M. Ortiz, Douglas F. Nixon, Alexandra Trkola, James Binley, Xia Jin, Sebastian Bonhoeffer, Peter J. Kuebler, Sean M. Donahoe, Marie-Ange Demoitie, William M. Kakimoto, Tom Ketas, Brian Clas, Jonas J. Heymann, Linqi Zhang, Yunzhen Cao, Arlene Hurley, John P. Moore, David D. Ho, Martin Markowitz
J Clin Invest.
1999;
104(6):0–0
doi:10.1172/JCI7371
This article Copyright © 1999, The American Society for Clinical Investigation
Abstract
|
Full text
|
PDF
T
herapeutic intervention with highly active antiretroviral therapy (HAART) can lead to suppression of HIV-1 plasma viremia to undetectable levels for 3 or more years. However, adherence to complex drug regimens can prove problematic, and subjects may temporarily discontinue HAART for variable periods. We studied 6 HIV-1–infected individuals who stopped therapy. Off HAART, levels of viremia were suppressed to fewer than 500 copies/mL in 2 subjects for more than 12 and more than 24 months, respectively, and in 1 subject for 4 months on 1 occasion. Three subjects failed to contain plasma viremia. Broad and strong HIV-1–specific immune responses were detected in subjects with prolonged suppression of viral replication. This longitudinal study suggests that containment of HIV-1 replication to low or undetectable levels after discontinuation of HAART is associated with strong virus-specific immune responses. Boosting of HIV-1–specific immune responses should be considered as an adjunctive treatment strategy for HIV-1–infected individuals on HAART.
This file is in Adobe Acrobat (PDF) format.
If you have not installed and configured the Adobe Acrobat Reader on your system.
Having trouble reading a PDF?
PDFs are designed to be printed out and read, but if you prefer to read them online, you may find it easier if you increase the view size to 125%.
Having trouble saving a PDF?
Many versions of the free Acrobat Reader do not
allow Save. You must instead save the PDF from the JCI Online page you downloaded it from. PC users:
Right-click on the Download link and choose the option that says something like "Save Link As...".
Mac users should hold the mouse button down on the link to get these same options.
Having trouble printing a PDF?
- Try printing one page at a time or to a newer printer.
- Try saving the file to disk before printing rather than opening it "on the fly." This requires that you
configure your browser to "Save" rather than "Launch Application" for the file type "application/pdf", and can
usually be done in the "Helper Applications" options.
- Make sure you are using the latest version of Adobe's Acrobat Reader.
