Misfolding of exportable proteins can trigger endocrinopathies. For example, misfolding of insulin can result in autosomal dominant mutant
Jordan Wright, Xiaofan Wang, Leena Haataja, Aaron P. Kellogg, Jaemin Lee, Ming Liu, Peter Arvan
Secretory rescue and stabilization of mutant proinsulin or Tg by their WT counterparts is linked to the WT/mutant expression ratio.