Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis
J. Clin. Invest. Lin Chen, et al. 104:1517 doi:10.1172/JCI6690 [Go to this article.]

Figure 3
The Gly369Cys mutation in mouse FGFR3 results in dwarf mice. (a) Morphology and (b) skeleton of 21 day old wild-type (WT), Fgfr3^369/+ (369/+), and Fgfr3^369/369 (369/369) mice. Notice dome-shaped heads in 369/+ and 369/369 mice (arrows). (c) Quantitative measurements of tail length of mice with 3 genotypes. Each point represents data from an average of 5 mice. Standard deviation is less than ± 5%. (d) X-ray images of 369/369 and WT mice. Notice the reduced bone density in 369/369 mice: F, femur; T, tibia.