The formation of clathrin-coated vesicles is essential for intracellular membrane trafficking between subcellular compartments and is triggered by the ARF family of small GTPases. We previously identified SMAP1 as an ARF6 GTPase-activating protein that functions in clathrin-dependent endocytosis. Because abnormalities in clathrin-dependent trafficking are often associated with oncogenesis, we targeted
Shunsuke Kon ... Takuro Nakamura, Masanobu Satake
ARF6 activation and transferrin endocytosis in bone marrow cells.
Copyright © 2014 American Society for Clinical Investigation