Spry2 and Pten inactivation synergistically drive murine prostate carcinogenesis.
(A) Representative H&E-stained images of alterations in prostates from mice as indicated (n = 6). Scale bars: 50 μm. (B) Representative prostate image and relative prostate weight of indicated mice at 12 months (*P < 0.01, n = 6, analyzed by Mann-Whitney Test). SV, seminal vesicles; AP, anterior prostate, DLP, dorsolateral prostate; B, bladder. Box and whisker plot shows median (lines within boxes), interquartile range (bounds of boxes), and upper and lower range (whiskers). (C) Representative IHC images of prostate tissue from 12-month-old mice as indicated (n = 6). Scale bars: 50 μm. (D) Representative IHC images for pancytokeratin staining in lymph nodes from indicated mice (n = 5). Scale bars: 50 μm.