J Clin Invest.
ACA11 is overexpressed in bladder, colon, and esophageal cancers.
(A–C) ACA11 is overexpressed in samples from patients with (A) bladder, (B) colon, and (C) esophageal cancer. Heat maps of RNA expression at the ACA11 locus were measured using our custom chromosome 4 tiling arrays. Each bar represents the normalized mean expression value obtained from quadruplicate probes representing each physical location. Numbers indicate base pairs on chromosome 4 (human genome assembly GRCh37). (D–F) Graphs of data shown in A–C. ACA11 levels in (D) bladder, (E) colon, and (F) esophagus samples were plotted using raw expression values of 4 probes. Intron, intron 18–19 of WHSC1 upstream of ACA11. Data in D–F are presented as mean ± SD (n = 4). M, malignant tumor samples. N, normal control samples.