Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
J. Clin. Invest. Aimee Y. Yu, et al. 103:691 doi:10.1172/JCI5912 [
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Figure 2Development of right ventricular hypertrophy in response to chronic hypoxia. The mass ratio of the right ventricle (
RV) to left ventricle and septum (
LV+S) was determined for the same
Hif1a+/+ (
open bars) and
Hif1a+/– (
closed bars) mice analyzed in Fig.
1. Results are expressed as mean ± SE. ANOVA with a
post hoc Dunnet's test revealed a significant difference between genotypes (
P = 0.0001). *
P < 0.01 ; **
P < 0.001 (Student's
t test).
