Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
J. Clin. Invest. Aimee Y. Yu, et al. 103:691 doi:10.1172/JCI5912 [
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Figure 1Development of polycythemia in mice subjected to chronic hypoxia. Hematocrits of
Hif1a+/+ (
open bars) and
Hif1a+/– (
closed bars) mice exposed to room air or 10% O
2 for 1–6 weeks were determined. Results are expressed as mean ± SE (
n = 8–10 mice for 0–5 weeks;
n = 5–7 mice for 6 weeks). ANOVA with a
post hoc Dunnet's test revealed a significant difference between genotypes (
P = 0.025).
