Effect of neutralizing antibody against IL-17 on OCL formation in cocultures of mouse bone marrow cells and osteoblasts in the presence of IL-17 (1 ng/mL), 1α,25(OH)₂D₃ (10^–8 M), PTH (200 ng/mL), and IL-1β (10 ng/mL). Concentrations of antibody against IL-17 were 2.5 μg/mL for experiments with IL-17 and 5 μg/mL for those with 1α,25(OH)₂D₃, PTH, and PGE₂. After culture for 6 days, TRAP-positive OCLs were counted. Data are expressed as the means ± SEM of quadruplicate cultures. Experiments were repeated 5 times with similar results.