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Heme oxygenase-1 gene induction as an intrinsic regulation against delayed cerebral vasospasm in rats
Hidenori Suzuki, Kenji Kanamaru, Hiroshi Tsunoda, Hiroyasu Inada, Minoru Kuroki, Hong Sun, Shiro Waga, Toshio Tanaka
Published in Volume 104, Issue 1
J Clin Invest. 1999; 104(1):59–66 doi:10.1172/JCI5357
This article Copyright © 1999, The American Society for Clinical Investigation
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Figure 6

(a) Cisternal levels of OxyHb and DeoxyHb in the 1-hemorrhage rats after treatment with antisense HO-1 ODN (circles, n = 3), sense HO-1 ODN (squares, n = 3), or scrambled ODN (triangles, n = 3). Significantly different from the baseline values on day 0 (aP < 0.025, bP < 0.001). Significantly different from the values for the antisense HO-1 ODN treatment (cP < 0.05, dP < 0.005). (b) Cisternal levels of MetHb in the same samples as a. Significantly different from the baseline values on day 0 (aP < 0.025). No significant differences were observed among the 3 groups.

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