Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein
J. Clin. Invest. Fayez F. Safadi, et al. 103:239 doi:10.1172/JCI5244 [Go to this article.]

Figure 3
Low serum 25(OH)D and 1,25(OH)₂D levels and secondary hyperparathyroidism after mild dietary vitamin D deficiency in DBP^–/– mice. Groups of DBP^+/+, DBP^+/–, and DBP^–/– mice were fed either standard (vitamin D⁺) (a–c) or vitamin D–deficient (vitamin D^–) (d–f) diets for 4 weeks. Serum 25(OH)D (a and d), 1,25(OH)₂D (b and e), and PTH (c and f) levels were determined. Data displayed are the mean + SEM from 10 animals. The differences between DBP^+/+ and DBP^–/– groups were statistically significant in a, b (**P < 0.001), and f (*P < 0.01). PTH, parathyroid hormone.