Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection
J. Clin. Invest. Barton F. Haynes, et al. 103:453 doi:10.1172/JCI5201 [Go to this article.]

Figure 2
Lack of correlation of presence of a thymus shadow on computerized tomogram of the mediastinum with thymus tissue containing active thymopoiesis by histologic analysis. (a) Computerized tomogram of patient no. 5 in January 1998. Arrowheads point to a triangular thymus shadow typical for an adult. (b) Immunohistological analysis using antikeratin antibody of the thymus tissue taken at autopsy 2 days after the computerized tomogram in a, demonstrating empty keratin⁺ thymic epithelium (e; brown areas) surrounded by an inflammatory-cell infiltrate (blue areas, arrows) in thymic perivascular space (P). ×33. No CD1a⁺ lymphocytes were present in the epithelial thymus; rather, the phenotype of mononuclear cells in the perivascular space demonstrated that the infiltrate contained monocytes, B cells, and mature CD8⁺ T cells, a subset of which was TIA-1⁺(not shown).