J Clin Invest.
Increased exercise performance and ambulatory activity in IL-15Rα–KO mice.
(A) Running distance per hour in IL-15Rα–KO mice (n = 12) and B6129 mice (n = 8). Gray indicates dark phase. (B) The total number of wheel revolutions during the 14-hour data collection period was 6-fold greater in IL-15Rα–KO mice compared with B6129 mice. The dashed line represents wheel running data in C57BL/6 wild-type mice. (C) Ambulatory activity in separate cohorts of IL-15Rα–KO mice (n = 8) and B6129 mice (n = 8). The number of ambulatory counts was significantly greater when expressed as (D) average counts in a 24-hour period, (E) total ambulatory counts during the 12-hour light cycle, and (F) total ambulatory counts during the 12-hour dark cycle. Knockout and background control mice were analyzed by t test, and data are presented as mean ± SD. *P < 0.05, **P < 0.001, ***P < 0.0001.