Advertisement

Citations to this article

Abstract

Androgenetic alopecia (AGA), also known as common baldness, is characterized by a marked decrease in hair follicle size, which could be related to the loss of hair follicle stem or progenitor cells. To test this hypothesis, we analyzed bald and non-bald scalp from AGA individuals for the presence of hair follicle stem and progenitor cells. Cells expressing cytokeratin15 (KRT15), CD200, CD34, and integrin, α6 (ITGA6) were quantitated via flow cytometry. High levels of KRT15 expression correlated with stem cell properties of small cell size and quiescence. These KRT15hi stem cells were maintained in bald scalp samples. However, CD200hiITGA6hi and CD34hi cell populations — which both possessed a progenitor phenotype, in that they localized closely to the stem cell–rich bulge area but were larger and more proliferative than the KRT15hi stem cells — were markedly diminished. In functional assays, analogous CD200hiItga6hi cells from murine hair follicles were multipotent and generated new hair follicles in skin reconstitution assays. These findings support the notion that a defect in conversion of hair follicle stem cells to progenitor cells plays a role in the pathogenesis of AGA.

Authors

Luis A. Garza ... John W. Tobias, George Cotsarelis

×

Total citations by year in Crossref

Year: 2015 2014 2013 2012 2011 Total
Citations: 2 9 9 10 5 35
Citation information

Citations to this article in Crossref (35)

Title and authors Publication Year
Translational Regenerative Medicine
K Kobielak, E Kandyba, Y Leung
Translational Regenerative Medicine 2015
A new hypothesis of aging
AG Diaconeasa, M Rachita, RI Staden
Medical Hypotheses 2015
Principles of Tissue Engineering
D Gay, MV Plikus, E Treffeisen, A Wang, G Cotsarelis
Principles of Tissue Engineering 2014
Principles of Tissue Engineering
H Obokata, CA Vacanti
Principles of Tissue Engineering 2014
Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges: Prospects & Overviews
TS Purba, IS Haslam, E Poblet, F Jiménez, A Gandarillas, A Izeta, R Paus
BioEssays 2014
Inflammation, Advancing Age and Nutrition
CC Yang, CC Chen, WC Chen
Inflammation, Advancing Age and Nutrition 2014
Decreased CD200R expression on monocyte-derived macrophages correlates with Th17/Treg imbalance and disease activity in rheumatoid arthritis patients
S Gao, B Hao, XF Yang, WQ Chen
Inflammation Research 2014
Morphological and morphometric study of the androgenetic alopecic scalp using two- and three-dimensional analysis comparing regional differences
JN Kim, JY Lee, KJ Shin, YC Gil, KS Koh, WC Song
The British journal of dermatology 2014
Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies
BA Fioret, AK Hatzopoulos
Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies 2014
Platelet-Rich Plasma for Androgenetic Alopecia: A Pilot Study
G Schiavone, D Raskovic, J Greco, D Abeni
Dermatologic Surgery 2014
Hair follicle morphogenesis and epidermal homeostasis in we/we wal/wal mice with postnatal alopecia
A Rippa, V Terskikh, A Nesterova, A Vasiliev, E Vorotelyak
Histochemistry and Cell Biology 2014
New investigational drugs for androgenetic alopecia
IC de Sousa, A Tosti
Expert Opinion on Investigational Drugs 2013
Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers
M Rathman-Josserand, G Genty, J Lecardonnel, S Chabane, A Cousson, JF Michelet, BA Bernard
Journal of Investigative Dermatology 2013
Comparison between fibroblasts and mesenchymal stem cells derived from dermal and adipose tissue
CA Brohem, CM de Carvalho, CL Radoski, FC Santi, MC Baptista, BB Swinka, CA Urban, LR de Araujo, RM Graf, IH Feferman, M Lorencini
International Journal of Cosmetic Science 2013
Conduite diagnostique à tenir devant une alopécie
C Droitcourt
Revue Francophone des Laboratoires 2013
Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche
MJ Harries, K Meyer, I Chaudhry, J Kloepper, E Poblet, CE Griffiths, R Paus
The Journal of Pathology 2013
Ageing and colony-forming efficiency of human hair follicle keratinocytes
J Lecardonnel, N Deshayes, G Genty, N Parent, BA Bernard, M Rathman-Josserand, M Paris
Experimental Dermatology 2013
Skinomics: past, present and future for diagnostic microarray studies in dermatology
M Blumenberg
Expert Review of Molecular Diagnostics 2013
Possible role of autophagy activation in stimulation of regeneration
KS Vishnyakova, KV Popov, EA Vorotelyak, RR Faizullin, AS Artyukhov, YE Yegorov
Molecular Biology 2013
Establishment and molecular characterization of human dermal mesenchymal-like stem cells derived from human scalp biopsy of androgenetic alopecia patient
P Potdar, KS Kumar
Stem Cell Discovery 2013
Dialogues in Dermatology: Highlights from 2011
JP Lott, D Robinson, C Warren, R Klein, B Craiglow, M Girardi
Journal of the American Academy of Dermatology 2012
Stem cells and alopecia: a review of pathogenesis: Stem cells and alopecia
K Al-Refu
British Journal of Dermatology 2012
Hair regrowth in a male patient with extensive androgenetic alopecia on estrogen therapy
P Adenuga, P Summers, W Bergfeld
Journal of the American Academy of Dermatology 2012
A prototypic mathematical model of the human hair cycle
Y Al-Nuaimi, M Goodfellow, R Paus, G Baier
Journal of Theoretical Biology 2012
What’s New in the Histologic Evaluation of Alopecia and Hair-Related Disorders?
DM Elston
Dermatologic Clinics 2012

Advertisement
Advertisement