Citations to this article


Androgenetic alopecia (AGA), also known as common baldness, is characterized by a marked decrease in hair follicle size, which could be related to the loss of hair follicle stem or progenitor cells. To test this hypothesis, we analyzed bald and non-bald scalp from AGA individuals for the presence of hair follicle stem and progenitor cells. Cells expressing cytokeratin15 (KRT15), CD200, CD34, and integrin, α6 (ITGA6) were quantitated via flow cytometry. High levels of KRT15 expression correlated with stem cell properties of small cell size and quiescence. These KRT15hi stem cells were maintained in bald scalp samples. However, CD200hiITGA6hi and CD34hi cell populations — which both possessed a progenitor phenotype, in that they localized closely to the stem cell–rich bulge area but were larger and more proliferative than the KRT15hi stem cells — were markedly diminished. In functional assays, analogous CD200hiItga6hi cells from murine hair follicles were multipotent and generated new hair follicles in skin reconstitution assays. These findings support the notion that a defect in conversion of hair follicle stem cells to progenitor cells plays a role in the pathogenesis of AGA.


Luis A. Garza ... John W. Tobias, George Cotsarelis


Total citations by year in Crossref

Year: 2014 2013 2012 2011 Total
Citations: 13 13 18 8 52
Citation information

Citations to this article in Crossref (52)

Title and authors Publication Year
The Thinning Top: Why Old People Have Less Hair
SK Reddy, LA Garza
Journal of Investigative Dermatology 2014
Platelet-Rich Plasma for Androgenetic Alopecia: A Pilot Study
G Schiavone, D Raskovic, J Greco, D Abeni
Dermatologic Surgery 2014
Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies
BA Fioret, AK Hatzopoulos
Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies 2014
Morphological and morphometric study of the androgenetic alopecic scalp using two- and three-dimensional analysis comparing regional differences
JN Kim, JY Lee, KJ Shin, YC Gil, KS Koh, WC Song
The British journal of dermatology 2014
Transit-Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration
YC Hsu, L Li, E Fuchs
Cell 2014
Decreased CD200R expression on monocyte-derived macrophages correlates with Th17/Treg imbalance and disease activity in rheumatoid arthritis patients
S Gao, B Hao, XF Yang, WQ Chen
Inflammation Research 2014
Inflammation, Advancing Age and Nutrition
CC Yang, CC Chen, WC Chen
Inflammation, Advancing Age and Nutrition 2014
Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges: Prospects & Overviews
TS Purba, IS Haslam, E Poblet, F Jiménez, A Gandarillas, A Izeta, R Paus
BioEssays 2014
Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells
R Yang, Y Zheng, M Burrows, S Liu, Z Wei, A Nace, W Guo, S Kumar, G Cotsarelis, X Xu
Nature Communications 2014
Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4
CC Chen, PJ Murray, TX Jiang, MV Plikus, YT Chang, OK Lee, RB Widelitz, CM Chuong
Journal of Investigative Dermatology 2014
Principles of Tissue Engineering
D Gay, MV Plikus, E Treffeisen, A Wang, G Cotsarelis
Principles of Tissue Engineering 2014
Does prostaglandin D 2 hold the cure to male pattern baldness?
A Nieves, LA Garza
Experimental Dermatology 2014
Principles of Tissue Engineering
H Obokata, CA Vacanti
Principles of Tissue Engineering 2014
Keratin k15 as a biomarker of epidermal stem cells
A Bose, MT Teh, IC Mackenzie, A Waseem
International journal of molecular sciences 2013
Ageing and colony-forming efficiency of human hair follicle keratinocytes
J Lecardonnel, N Deshayes, G Genty, N Parent, BA Bernard, M Rathman-Josserand, M Paris
Experimental Dermatology 2013
Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche
MJ Harries, K Meyer, I Chaudhry, J Kloepper, E Poblet, CE Griffiths, R Paus
The Journal of Pathology 2013
Possible role of autophagy activation in stimulation of regeneration
KS Vishnyakova, KV Popov, EA Vorotelyak, RR Faizullin, AS Artyukhov, YE Yegorov
Molecular Biology 2013
Conduite diagnostique à tenir devant une alopécie
C Droitcourt
Revue Francophone des Laboratoires 2013
Comparison between fibroblasts and mesenchymal stem cells derived from dermal and adipose tissue
CA Brohem, CM de Carvalho, CL Radoski, FC Santi, MC Baptista, BB Swinka, CA Urban, LR de Araujo, RM Graf, IH Feferman, M Lorencini
International Journal of Cosmetic Science 2013
Many Paths to Alopecia via Compromised Regeneration of Hair Follicle Stem Cells
J Li, TX Jiang, CM Chuong
Journal of Investigative Dermatology 2013
Clinical efficacy of a cosmetic treatment by Crescina(®) human follicle stem cell on healthy males with androgenetic alopecia
D Buonocore, V Nobile, A Michelotti, F Marzatico
Dermatology and Therapy 2013
Isolation of Multipotent Nestin-Expressing Stem Cells Derived from the Epidermis of Elderly Humans and TAT-VHL Peptide-Mediated Neuronal Differentiation of These Cells
H Kanno, A Kubo, T Yoshizumi, T Mikami, J Maegawa
International journal of molecular sciences 2013
Human Hair Follicle Stem/Progenitor Cells Express Hypoxia Markers
M Rathman-Josserand, G Genty, J Lecardonnel, S Chabane, A Cousson, JF Michelet, BA Bernard
Journal of Investigative Dermatology 2013
New investigational drugs for androgenetic alopecia
IC de Sousa, A Tosti
Expert Opinion on Investigational Drugs 2013
Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering
SC Chueh, SJ Lin, CC Chen, M Lei, LM Wang, R Widelitz, MW Hughes, TX Jiang, CM Chuong
Expert Opinion on Biological Therapy 2013