Hepatocyte growth factor leads to recovery from alcohol-induced fatty liver in rats
J. Clin. Invest. Minoru Tahara, et al. 103:313 doi:10.1172/JCI4433 [
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Figure 4Effects of HGF on lipid mobilization in primary cultured hepatocytes prepared from rat with fatty liver caused by ingestion of ethanol diets. Changes in hepatocellular triglyceride contents (
a), accumulation of lipid droplets (
b), and triglyceride levels in secreted VLDL fractions (
c) are shown. Hepatocytes prepared from rat treated with ethanol diets for 5 weeks were cultured for 48 h in the absence or presence of 20 ng/ml HGF. In
b, lipid droplets in hepatocytes were detected using an oil red O method. Each value represents the mean ± SD of triplicate measurements. *
P < 0.05. Bars, 50 μm.
VLDL, very-low-density lipoprotein.
