Rachel R. Caspi
J Clin Invest.
2010;
120(9):3073–3083
doi:10.1172/JCI42440
This article Copyright © 2010, The American Society for Clinical Investigation
Abstract
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utoimmune and inflammatory uveitis are a group of potentially blinding intraocular inflammatory diseases that arise without a known infectious trigger and are often associated with immunological responses to unique retinal proteins. In the United States, about 10% of the cases of severe visual handicap are attributed to this group of disorders. As I discuss here, experimental models of ocular autoimmunity targeting retinal proteins have brought about a better understanding of the basic immunological mechanisms involved in the pathogenesis of uveitis and are serving as templates for the development of novel therapies.
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