Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice
J. Clin. Invest. 119:11 doi:10.1172/JCI39939
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Figure 3
Induction of IFN-β by activation of TLR4, but not TLR3, is abnormal in Hfe KO macrophages.

WT and Hfe KO macrophages were stimulated with (A) 100 ng/ml LPS or (B) 10 μg/ml poly(I:C) for 6 hours (n = 3 per group). Supernatants were collected and analyzed by ELISA for IFN-β. Data represent mean ± SD. Similar results were obtained in 2 separate experiments. *P = 0.026; **P = 0.039.