Suppression of K_ATP channel activity protects murine pancreatic β cells against oxidative stress
J. Clin. Invest. 119:11 doi:10.1172/JCI38817 [Go to this article.]

Figure 2
Effect of H₂O₂ on electrical activity in Sur1^–/– and WT β cells.

(A) Registration of V_m in the presence of 15 mM glucose (G15). Time of addition of 100 μM H₂O₂ is denoted by horizontal bars. Results show 1 representative of 4 experiments with WT β cells and 10 with Sur1^–/– β cells. (B) Quantification of changes in V_m evoked by addition of 10, 25, and 100 μM H₂O₂ in WT and Sur1^–/– β cells. (C) Changes in AP frequency evoked by addition of 10, 25, and 100 μM H₂O₂ in WT and Sur1^–/– β cells. APs completely disappeared in WT β cells in 6 of 9 experiments with 10 μM H₂O₂, 3 of 6 with 25 μM H₂O₂, and 3 of 4 with 100 μM H₂O₂. n is given within each bar. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 versus respective control.